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Q Do paroxetine and psychotherapy reduce recurrent episodes of depression in the elderly?
Two by two randomised controlled trial (randomisation stratified by number of episodes, use of additional pharmacotherapy, and degree of cognitive impairment).
Double blinded (for drug treatment).
Follow up period:
A university based clinic, Pittsburgh, USA; 1999 to 2005.
116 people (⩾70 years old) who achieved a recovery from major depression (DSM-IV and a score of ⩾15 on the Hamilton Rating Scale for Depression and ⩾17 on the Folstein Mini-Mental State Examination) with open label paroxetine (10 mg daily initially, titrated up to 40 mg daily if necessary) and psychotherapy. A recovery was defined as a Hamilton score of 0 to 10 for three consecutive weeks, maintained over another 16 weeks of paroxetine and psychotherapy. Participants could receive additional pharmacotherapy (lithium, bupropion, or nortriptyline).
Maintenance treatment …
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