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Residual mood symptoms and number of previous episodes predict recurrence of bipolar disorder

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Q What factors are associated with recurrence in people with bipolar disorder?

METHODS

Embedded ImageDesign:

Prospective cohort study.

Embedded ImageFollow up period:

Up to 24 months (median 94.5 weeks).

Embedded ImageSetting:

Systematic Treatment Enhancement Program for Bipolar Disorder, multiple centres, USA; time period not stated.

Embedded ImagePeople:

858 people aged 15 years or older with DSM-IV bipolar disorder, who were symptomatic at study entry (⩾3 clinically significant symptoms at study entry or over the preceding 8 weeks) and recovered (⩽2 clinically significant symptoms for at least 8 weeks) during the 2 year follow up period.

Embedded ImageRisk factors:

Residual mood symptoms (clinically significant or subsyndromal) at recovery; axis I comorbidity (DSM-IV); prior number of episodes. Cox regression models were used to assess the association …

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