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Q What factors are associated with recurrence in people with bipolar disorder?
Prospective cohort study.
Follow up period:
Up to 24 months (median 94.5 weeks).
Systematic Treatment Enhancement Program for Bipolar Disorder, multiple centres, USA; time period not stated.
858 people aged 15 years or older with DSM-IV bipolar disorder, who were symptomatic at study entry (⩾3 clinically significant symptoms at study entry or over the preceding 8 weeks) and recovered (⩽2 clinically significant symptoms for at least 8 weeks) during the 2 year follow up period.
Residual mood symptoms (clinically significant or subsyndromal) at recovery; axis I comorbidity (DSM-IV); prior number of episodes. Cox regression models were used to assess the association between predictors and time to recurrence.
Rate of recurrence (defined as meeting the full DSM-IV criteria for mania, hypomania, mixed state or depressive episode on any follow …
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