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Q What clinical and demographic variables predict serious adverse events in people with bipolar disorder?
Prospective cohort study.
Follow up period:
Systematic Treatment Enhancement Program for Bipolar Disorder, multiple centres, USA; November 1999 to April 2002.
1000 people aged 15 years or older with DSM-IV bipolar disorder (bipolar I or II disorder, cyclothymia, bipolar disorder not otherwise specified, or schizoaffective disorder, bipolar subtype).
A large number of potential risk factors present at study entry were considered, including bipolar illness related variables (age at onset of bipolar illness, duration of illness, bipolar subtype, number of psychotropic medications, number of mood episodes, history of rapid cycling), other psychiatric variables (suicidal ideation, comorbid axis I diagnoses, family psychiatric history), and demographic variables (age, race, gender, marital status, and household income). Logistic regression was used to determine the association between predictors and outcome.
Serious adverse events (defined as any of the …
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