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Q Is suicide risk related to antidepressant type (newer or older antidepressant) or greater in the first month after treatment initiation?
Retrospective cohort study.
Follow up period:
6 months following initial antidepressant prescription.
Members of a prepaid health plan in Washington and Idaho, USA.
65 203 people starting a new episode of antidepressant treatment between January 1992 and June 2003.
Treatment with a newer antidepressant (bupropion, citalopram, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline, escitalopram, venlafaxine) or older antidepressant (primarily tricyclic antidepressants (76%) and trazodone (21%)).
Suicide attempt requiring hospitalisation (verified through hospital discharge records) or death by suicide (verified through death certificate).
The newer antidepressants did not increase risk of suicide attempt or suicide death compared with the older drugs after six months of treatment (suicide attempt: adjusted OR 0.9, 95% …
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