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Review: an early sustained response can occur in the first and second weeks of antidepressant treatment for major depressive disorder

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 Q Do antidepressants increase early sustained response compared with placebo in people with major depression?

METHODS

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Systematic review with meta-analyses.

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MEDLINE and PubMed; search date not stated.

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Eligible studies were double blind, placebo controlled randomised controlled trials (RCTs) and meta-analyses of such RCTs that compared antidepressants versus placebo in people with major depressive disorder, and reported early sustained response rates. For inclusion studies had to define: early response as a clinical response within the first 2 weeks; clinical response as a Clinical Global Impression—Improvement (CGI-I) score <3, or ⩾50% reduction in Hamilton Depression Rating Scale (HDRS) scores; an early sustained response as one which was not followed by a worsening of symptoms. …

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