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Vardenafil improves comorbid erectile dysfunction and mild depression

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 Q Does vardenafil improve erectile dysfunction and mild major depressive disorder in men with both disorders?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Not stated.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

12 weeks.

Embedded ImageSetting:

44 centres in the USA, Canada, France, Spain and Italy; December 2002 to November 2003.

Embedded ImagePatients:

280 men aged 18 and over with erectile dysfunction for longer than 6 months (National Institutes of Health criteria) and untreated depressive disorder (a score of 13–23 (later modified to 11–17) on the Hamilton Depression Rating Scale and >13 on Center for Epidemiologic Studies Depression Scale) who had been in a heterosexual relationship for >6 months at study entry. Exclusions: serious risk of homicide or suicide; history of psychotic disorders, panic …

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