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Mirtazapine reduces social anxiety and improves quality of life in women with social phobia

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 Q Does mirtazapine improve symptoms and quality of life in women with social phobia?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

10 weeks.

Embedded ImageSetting:

General population, Germany; September to December 2004.

Embedded ImagePatients:

66 women with social phobia (DSM-IV). Exclusions: <18 years old; psychosis; severe major depressive episode; pregnancy; not using contraception; psychotherapy; suicidal; abusing drugs or alcohol; other illness; or current use of mirtazapine or other psychotropics.

Embedded ImageIntervention:

Mirtazapine (30 mg/day); placebo.

Embedded ImageOutcomes:

Social anxiety (Social Phobia Inventory (SPIN); Liebowitz Social Anxiety Scale (LSAS)); quality of life (SF-36 Health Survey).

Embedded ImagePatient follow up:

89% at 10 weeks.

MAIN RESULTS

At 10 weeks, mirtazapine improved symptoms of social anxiety …

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