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Q Is topiramate effective for reducing psychological stress and interpersonal problems, and improving quality of life, in women with borderline personality disorder?
Randomised controlled trial.
Follow up period:
General population, Germany; May 2004 – May 2005.
56 women (mean age 25 years; range 18–35) with borderline personality disorder (DSM-IV). Exclusions: schizophrenia; pregnancy; not using contraception; suicidality; drug or alcohol abuse; other illness; or already using topiramate or other psychotropic drugs.
Topiramate (titrated from 25 mg/day in week 1 to 200 mg/day in week 6 and maintained at this dose for the last four weeks of the study); or placebo for 10 weeks.
Psychopathological symptoms (Symptom Checklist (SCL-90-R)), quality of life (SF-36 Health Survey), …
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