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Olanzapine is associated with more rapid weight gain than haloperidol in people with first episode psychosis

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 Q How much weight is gained by people taking olanzapine or haloperidol for first episode psychosis?

METHODS

Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:

Unclear.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Two years.

Embedded ImageSetting:

14 academic medical centres in North America and Europe; March 1997 to July 2001.

Embedded ImagePatients:

263 people (aged 16–40 years) with DSM-IV schizophrenia, schizophreniform disorder, or schizoaffective disorder. Participants had experienced symptoms for 1–60 months, were defined as at least moderately ill, and in need of antipsychotic drugs. Exclusions: prior antipsychotic treatment for >16 weeks in total; having taken clozapine; currently receiving anticonvulsants, antidepressants, benzodiazepines (except for agitation and extrapyramidal symptoms), or other psychotropic medications.

Embedded ImageIntervention:

Olanzapine (5–10 mg/day in weeks 1–6; 5–20 mg/day in weeks 7–12) or haloperidol (2–6 mg/day in weeks 1–6; 2–20 mg/day in weeks …

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