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Q How much weight is gained by people taking olanzapine or haloperidol for first episode psychosis?
Multicentre randomised controlled trial.
Follow up period:
14 academic medical centres in North America and Europe; March 1997 to July 2001.
263 people (aged 16–40 years) with DSM-IV schizophrenia, schizophreniform disorder, or schizoaffective disorder. Participants had experienced symptoms for 1–60 months, were defined as at least moderately ill, and in need of antipsychotic drugs. Exclusions: prior antipsychotic treatment for >16 weeks in total; having taken clozapine; currently receiving anticonvulsants, antidepressants, benzodiazepines (except for agitation and extrapyramidal symptoms), or other psychotropic medications.
Olanzapine (5–10 mg/day in weeks 1–6; 5–20 mg/day in weeks 7–12) or haloperidol (2–6 mg/day in weeks 1–6; 2–20 mg/day in weeks …
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