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Q Is olanzapine more effective for treating neurocognitive deficits than risperidone or haloperidol in people with schizophrenia?
Randomised controlled trial.
Follow up period:
39 sites, USA and Canada; July 1999 to September 2000.
414 people with schizophrenia or schizoaffective disorder (DSM-IV; mean age 39 years; 71% men). Exclusions: <18 or >55 years old; fewer than two positive items on the Positive and Negative Symptoms scale with a score ⩾4; score <18 on the Brief Psychiatric Rating Scale; non-English speaking; <2 years since first diagnosis, treatment or hospitalisation; neurological disorder; head injury; serious illness; untreated hypothyroidism or hyperthyroidism; agranulocytosis; pregnant or nursing; substance dependence; treatment with depot antipsychotics, reversible monoamine oxidase inhibitor, clozapine, fluvoxamine, or lithium; prophylactic use of anticholinergics; electroconvulsive therapy in previous month; or allergic to study medication.
Olanzapine (5–20 mg/day, mean dose 12.3 …
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