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Review: higher rates of attrition in antipsychotic treatment arms of placebo controlled trials than in trials with active comparators

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Q Is attrition greater in the treatment arms of placebo controlled trials than in those of active comparator trials?

METHODS

Embedded ImageDesign:

Systematic review with meta-analysis of randomised controlled trials (RCTs)

Embedded ImageData sources:

PubMed, MEDLINE (published before October 2004)

Embedded ImageStudy selection and analysis:

Double blind RCTs of antipsychotics (placebo or active comparators) in unselected people with schizophrenia, or both schizophrenia and schizoaffective disorder, with 4–12 weeks duration, and >40 participants were included. Exclusion: trials of clozapine; trials in subpopulations of those with schizophrenia (for example, with schizoaffective disorder only). Analysis: random-effects linear regression was used to compare pooled dropout rates during active treatment (log odds ratios) between those studies with active comparators and those that were placebo controlled. Separate meta-analyses were performed for newer (second generation) and older …

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