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Q What is the rate of discontinuation of antidepressant treatment in adults with depression in the USA and what factors are associated with early discontinuation?
Retrospective cohort study.
Medical Expenditure Panel Survey (MEPS), USA, a national sample of the civilian population; 1996 to 2001.
829 people aged 18 and over who had initiated antidepressant treatment for depression (DSM-IV or ICD-9) during the survey period. Exclusions: use of mood stabilising medications.
Discontinuation of antidepressant treatment.
Follow up period:
Of adults treated with antidepressants, 42.4% discontinued medication within the first 30 days, and a further 30% discontinued medication within 31–90 days of starting treatment. Discontinuation of medication within the first 30 days was more common in Hispanic people (53.8% v 41.3% in non-Hispanic people; p<0.04), in …
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