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Q Does risperidone prevent relapse compared with placebo for children with autism spectrum disorders?
Randomised controlled trial.
Follow up period:
Thirty two weeks.
Groningen and Utrecht University Child and Adolescent Psychiatry Centres; time period not stated.
Thirty six children aged 5–17 years with an autism spectrum disorder (Autism Diagnostic Interview-Revised plus clinical judgement) enrolled in the open label phase, 24 children who responded to risperidone were randomised. Other enrolment criteria: at least moderate disruptive behaviour (tantrums, self-injury, and/or aggression) or on the Clinical Global Impressions of Severity (CGI-S) Scale; Irritability Scale score ⩾18 on the Aberrant Behaviour Checklist (ABC); weight ⩾15 kg; mental age ⩾18 months; …
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