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Review: atypical antipsychotic drugs slightly increase mortality rates in elderly people with dementia

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 Q Do atypical antipsychotic drugs increase mortality in people with dementia?

METHODS

Embedded ImageDesign:

Systematic review with meta-analysis.

Embedded ImageData sources:

MEDLINE (1966 to April 2005), Cochrane Controlled Trials Register (2005, issue 1), meeting presentations (1997 to 2004), and information from sponsors.

Embedded ImageStudy selection and analysis:

Studies were included if they were double blind, randomised, placebo controlled clinical trials of orally administered atypical antipsychotic drugs used to treat Alzheimer’s disease or dementia (vascular dementia, mixed dementia, and primary dementia). Both published and unpublished studies were included. Outcomes were assessed using fixed effect models to calculate odds ratio.

Embedded ImageOutcomes:

Deaths occurring during the trial period or within 30 days of discontinuing double blind treatment.

MAIN RESULTS

Fifteen trials (nine unpublished) met inclusion criteria. Atypical antipsychotic drugs increased mortality compared with placebo (death: 118/3353 (3.5%) …

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