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Q Do atypical antipsychotic drugs increase mortality in people with dementia?
Systematic review with meta-analysis.
MEDLINE (1966 to April 2005), Cochrane Controlled Trials Register (2005, issue 1), meeting presentations (1997 to 2004), and information from sponsors.
Study selection and analysis:
Studies were included if they were double blind, randomised, placebo controlled clinical trials of orally administered atypical antipsychotic drugs used to treat Alzheimer’s disease or dementia (vascular dementia, mixed dementia, and primary dementia). Both published and unpublished studies were included. Outcomes were assessed using fixed effect models to calculate odds ratio.
Deaths occurring during the trial period or within 30 days of discontinuing double blind treatment.
Fifteen trials (nine unpublished) met inclusion criteria. Atypical antipsychotic drugs increased mortality compared with placebo (death: 118/3353 (3.5%) …
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