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Combination treatment of behaviour therapy and medication significantly reduces obsessive-compulsive symptoms in people who have responded to pharmacotherapy

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 Q Does the addition of behaviour therapy to continuing medication benefit people with obsessive-compulsive disorder who have responded to drug treatment?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Unclear.

Embedded ImageBlinding:

Single blinded.

Embedded ImageFollow up period:

Twelve months.

Embedded ImageSetting:

University Medical Centre Utrecht, the Netherlands; October 1998 to June 2002.

Embedded ImagePatients:

Ninety six adult outpatients with DSM-IV obsessive-compulsive disorder (OCD) who had responded to three months of medication (⩾25% reduction in score on Yale-Brown Obsessive Compulsive Scale (Y-BOCS)) with venlafaxine (300 mg/day) or paroxetine (60 mg/day). Exclusion criteria: comorbid Axis I disorder during past six months; Hamilton Rating Scale for Depression score >16; and cognitive and/or behaviour therapy within six months of randomisation.

Embedded ImageIntervention:

People were allocated to continuing drug treatment (300 mg/day venlafaxine or 60 mg/day paroxetine) plus behaviour therapy …

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