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Adding sarcosine, but not D-serine, to risperidone improves symptoms in people with acute phase schizophrenia

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 Q Does adding sarcosine or D-serine to risperidone improve symptoms in people with acute phase schizophrenia?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Six weeks.

Embedded ImageSetting:

Two hospital inpatient units, Taiwan, from January 2000 to July 2003.

Embedded ImagePatients:

Sixty five people aged 18–60 years with acute exacerbation of DSM-IV schizophrenia (45% female). Exclusions: baseline Positive and Negative Syndrome Scale (PANSS) total score <60; abnormal urine, blood, biochemical, or electrocardiography results; substance abuse or dependence; smoker; received atypical antipsychotic; contrainidication to antipsychotics; or received depot antipsychotic in previous six months.

Embedded ImageIntervention:

D-serine (2 g/day) plus risperidone (titrated to 6 mg/day); sarcosine (2 g/day) plus risperidone; placebo plus risperidone.

Embedded ImageOutcomes:

Psychopathological changes (PANSS; Scale for Assessment of Negative Symptoms (SANS)).

Embedded ImagePatient follow up:



At six weeks, sarcosine plus risperidone improved symptoms for people with acute phase …

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