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Q Is olanzapine more effective than haloperidol in improving quality of life and social functioning in people with first episode psychosis?
Multicentre randomised controlled trial.
Follow up period:
Fourteen medical centres in North America and Western Europe; time period not reported.
263 people aged 16–40 years with first episode schizophrenic spectrum psychosis (DSM-IV) and active psychotic symptoms. Participants had to have less than five years of symptoms with any recovery period lasting less than six months, and antipsychotic treatment lasting 16 weeks or less.
After a 2–14 day washout of current medication, participants received either haloperidol (2–6 mg/day) or olanzapine (5–20 mg/day).
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