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Q Does a combination of olanzapine and fluoxetine lead to a greater reduction in symptoms in people with treatment resistant depression compared with either drug alone?
Multicentre randomised controlled trial.
Follow up period:
Seventy one sites in the United States and Canada; study started in August 1999.
500 people (age 18–65 years) with treatment resistant unipolar, non-psychotic, major depression disorder (DSM-IV; Montgomery-Åsberg Depression Rating Scale (MADRS) total score ⩾20). Participants had not responded to a selective serotonin reuptake inhibitor in the past, and also failed to respond to nortriptyline (<30% reduction in MADRS score) during a seven week lead-in phase. Exclusions: inability to maintain adequate blood nortriptyline levels, taking medications with primary CNS activity (except …
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