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Evid Based Mental Health 9:40 doi:10.1136/ebmh.9.2.40
  • Therapeutics

Risperidone effectively increases rates of symptomatic remission of acute mania in people with bipolar disorder


 
 Q Does risperidone increase symptomatic remission of acute mania in people with bipolar disorder?

METHODS

GraphicDesign:

Randomised controlled trial.

GraphicAllocation:

Unclear.

GraphicBlinding:

Double blind.

GraphicFollow up period:

Three weeks.

GraphicSetting:

Eight hospitals, India. Recruitment: March 2001 to December 2001.

GraphicPatients:

291 people (aged 18–65 years) with bipolar I disorder (manic or mixed) (DSM-IV; Young Mania Rating Scale (YMRS)). Exclusions: YMRS score <20; no previous history of mania; schizoaffective disorder; rapid cycling bipolar disorder; borderline or antisocial personality disorder; neuroleptic malignant syndrome; substance abuse or dependence; other medical conditions; pregnant or nursing; not taking contraception; or at risk of violent or suicidal behaviour.

GraphicIntervention:

The efficacy of risperidone in bipolar disorder was …