Risperidone effectively increases rates of symptomatic remission of acute mania in people with bipolar disorder
Q Does risperidone increase symptomatic remission of acute mania in people with bipolar disorder?
Randomised controlled trial.
Follow up period:
Eight hospitals, India. Recruitment: March 2001 to December 2001.
291 people (aged 18–65 years) with bipolar I disorder (manic or mixed) (DSM-IV; Young Mania Rating Scale (YMRS)). Exclusions: YMRS score <20; no previous history of mania; schizoaffective disorder; rapid cycling bipolar disorder; borderline or antisocial personality disorder; neuroleptic malignant syndrome; substance abuse or dependence; other medical conditions; pregnant or nursing; not taking contraception; or at risk of violent or suicidal behaviour.
The efficacy of risperidone in bipolar disorder was …