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Q Do antipsychotics improve psychosis within the first 24 hours for people with schizophrenia spectrum disorders who are experiencing agitation?
Randomised controlled trial.
Follow up period:
Several international hospitals; exact locations or time period not specified.
311 people diagnosed with schizophrenia, schizophreniform disorder, or schizoaffective disorder and exhibiting an episode of acute agitation due to psychosis (DSM-IV). Exclusions: aged under 18 years; scored <14 on the Positive and Negative Syndrome Scale (PANSS) excitement component; significant, unstable medical disorder; or too agitated to provide consent or cooperate.
Intramuscular olanzapine (10 mg); haloperidol (7.5 mg); or placebo. An optional second dose was administered two or more hours after the first dose and an optional third dose was administered four or more hours after the second dose. Benzodiazopines were allowed for people receiving >1 dose …
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