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Atomoxetine improves teacher rated symptoms in children with ADHD more than placebo

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 Q Is once-daily atomoxetine more effective than placebo at reducing attention deficit hyperactivity disorder (ADHD) symptoms displayed at school?

METHODS

Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Seven weeks.

Embedded ImageSetting:

Eight sites in the USA, two in Canada, and one in Puerto Rico.

Embedded ImagePatients:

153 children aged 8–12 years with ADHD (DSM-IV); with symptom severity on the investigator administered ADHD Rating Scale-IV-Teacher Version (ADHDRS-IV-Teacher:Inv) at least 1.0 standard deviation (SD) above age and gender norms, and at least 1.5 SD above norms on the Connors Parent Rating Scale. Exclusions: no teacher available to participate; serious intellectual deficit or medical illness; taking other psychotropic medication.

Embedded ImageIntervention:

Atomoxetine (maximum dose 1.8 mg/kg/day; n = 102) …

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