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Q Does risperidone improve repetitive behaviour and social and communication impairment in children and adolescents with autism?
Randomised controlled trial.
Follow up period:
Five universities, USA; time period not stated.
101 children and adolescents aged 12–17 years with autism and impairing behavioural symptoms (DSM-IV, Autism Diagnostic Interview (revised); mean age 8.8 years; 82% male). Exclusions: not stated.
Risperidone (0.5 to 3.5 mg/day); placebo.
Symptomatic behaviours (modified parent rated Ritvo-Freeman Real Life Scale (RFRLS), higher score indicates greater symptom severity).
Patient follow up:
At eight weeks, risperidone improved overall symptomatic behaviours compared with placebo (change in overall RFRLS score from baseline to …
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