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Epilepsy or a family history of epilepsy increases the risk of schizophrenia or schizophrenia-like psychosis

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 Q Does a personal history of epilepsy, family history of psychosis, or family history of epilepsy affect the risk of schizophrenia or schizophrenia-like psychosis?

METHODS

Embedded ImageDesign:

Retrospective population-based cohort study.

Embedded ImageFollow up period:

52 years.

Embedded ImageSetting:

General population, Denmark; population registers evaluated for years 1950 to 2002.

Embedded ImagePeople:

2 270 372 people born in Denmark between 1 January 1950 and 31 December 1987, whose mother could be identified. Exclusion criteria: death or emigration before 1977; death before the age of 15; admission to a psychiatric hospital before the onset of epilepsy; or admission with a schizophrenia-like psychosis before the age of 15.

Embedded ImageRisk factors:

Hospitalisation for epilepsy; age at onset of epilepsy; type of epilepsy (complex partial, other partial, generalised, …

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