Statistics from Altmetric.com
Systematic review with meta analysis.
MEDLINE (to April 2004), and manual search of selected journals (January 1980 to April 2004).
Study selection and analysis:
Studies were included if they were English language randomised controlled trials (RCTs) comparing two or more strategies for switching between two non-depot antipsychotic medications, including abrupt or gradual discontinuation of current medication and abrupt or gradual replacement with new medication. Meta-analysis was conducted to calculate correlation measure of effect size (r) for outcomes common to more than one study. These were calculated separately for the discontinuation and the replacement phases of the trials.
Symptoms (including Clinical Global Impressions—Severity Scale; Positive and Negative Syndrome Scale); adverse events (including …
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