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Q Are mixed amphetamine salts plus divalproex sodium safe and effective in children with bipolar disorder and comorbid ADHD after stabilisation of manic symptoms with divalproex sodium?
Randomised controlled crossover trial.
Follow up period:
Two weeks randomised treatment; 12 weeks open label follow up.
One hospital in Dallas, Texas, USA.
Thirty one children (mean age 9.8 years) with DSM-IV diagonosed bipolar I or II disorder and attention deficit hyperactivity disorder (ADHD). Eligible children had a Conner’s Teachers and Parents Rating Scales hyperactivity score ⩾2 standard deviations above normal and Young Mania Rating Scale (YMRS) score ⩾14, whose manic symptoms stabilised after eight weeks’ treatment with divalproex sodium. Main exclusions: other major …
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