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QUESTION: Are childhood biopsychosocial risk factors associated with juvenile onset different from those associated with adult onset major depressive disorder (MDD)?
Birth cohort followed for 26 years (Dunedin Multidisciplinary Health and Development Study).
Dunedin, New Zealand.
1037 children (91% of eligible births) who were born between April 1972 and March 1973 and participated in the first follow up assessment at 3 years of age. 998 study participants (96% of the birth cohort) completed ≥2 psychiatric interviews at ages 11, 13, or 15 years and at 18, 21, or 26 years, and were included in the analysis.
Assessment of risk factors
Childhood risk factors were assessed up to 9 years of age: neurodevelopmental characteristics (perinatal insults, gross motor skills, and intelligence quotient); parental characteristics (mother’s internalising symptoms, including depression and anxiety, mother–child interactions, criminal conviction history, and parental disagreement about discipline); family characteristics (number of residence changes, socioeconomic status, unwanted sexual contact, and loss of a parent); and child behaviour and temperament (inhibited or undercontrolled temperament, peer problems, and depressive symptoms).
Main outcome measures
Relation of childhood risk factors to juvenile onset (diagnosis at ≤15 y) and adult onset (diagnosis at ≥18 y) MDD.
The participants comprised 4 groups: juvenile depressed (first diagnosed with MDD at age 10, 12, or 14 y with no subsequent episode [n=21]), adult depressed (first diagnosed with MDD at age 17, 20, or 25 y [n=314]), juvenile/adult depressed (first diagnosed with MDD at age 10, 12, or 14 y and whose depression recurred in adulthood by age 26 [n=34]), and never depressed (never diagnosed with MDD [n=629]). Juvenile onset with or without recurrence of MDD in adulthood was associated with more childhood risk factors than purely adult onset MDD (table⇓). No differences in childhood risk factors existed between the adult onset MDD group and the never depressed group except for being subjected to inappropriate sexual contact and more residence changes.
Early childhood risk factors differentiated juvenile onset from adult onset major depressive disorder.
In the Dunedin Multidisciplinary Health and Development Study, a base sample of 1037 children was followed at age 3 years with psychological, medical, and sociological measures as part of a longitudinal investigation of health and behaviour.
The study population is a non-clinical epidemiological sample, which makes the study very special. The retention rate is fantastic. Some problems exist because they use different DSM criteria among the samples (DSM-III, DSM-III-R, and DSM-IV). Overall the study is well done and replicates less sophisticated studies that used checklists.1 They report that childhood biopsychosocial risk factors before the age of 9 years are associated with childhood and adolescent onset depression that may or may not recur in adulthood rather than adult onset depression.
This study’s major shortcoming is the lack of structured 3 generational family history of psychiatric disorders. The authors asked parents about criminal history, and the mothers completed a questionnaire about internalising problems.
The most important take home message for clinicians is that juvenile onset depression that recurred in adulthood was characterised by a higher proportion of women, internalising problems, temperamental inhibition, adult anxiety, and history of parental loss in childhood than juvenile onset depression that did not recur in adulthood. Juvenile onset depression that did not recur in adulthood had a higher proportion of men, externalising behaviours (similar to Harrington et al’s findings2), perinatal problems, conduct disorder, MDD, crime by parents, and difficult temperament than juvenile onset depression that recurred in adulthood.
The adult onset depression group did not differ from the adult control group without depression in early childhood risk factors except for being subjected to undesired sexual contact.
Early childhood risk factors differentiated juvenile onset from adult onset major depressive disorder
Elizabeth Weller (commentator)
Web Extra Note
See: Family disadvantages in early life were associated with depression in adulthood.
Evidence-Based Mental Health 1999;2:96.
For correspondence: Dr S R Jaffee, Institute of Psychiatry, London, UK.
Sources of funding: National Institute of Mental Health and the UK Medical Research Council.
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