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Evid Based Mental Health 5:61 doi:10.1136/ebmh.5.2.61
  • Aetiology

Increased risk of Alzheimer's disease in mothers who gave birth to children with Down's syndrome before 35 years of age

Risk of Alzheimer's disease (AD) in parents of children with Down's syndrome

Risk factor Relative risk of AD (95% CI)
*Not statistically significant
Mothers giving birth at ≤35 years 4.8 (2.1 to 11.2)
Mothers giving birth at >35 years 1.8 (0.6 to 5.1)*
Fathers having a child at ≤35 years 1.0 (0.3 to 3.2)*
Fathers having a child at >35 years 1.2 (0.4 to 3.4)*

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