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Evid Based Mental Health 5:56 doi:10.1136/ebmh.5.2.56
  • Therapeutics

Review: progesterone or progestogens lead to a marginal reduction in premenstrual syndrome symptoms

Progesterone or progestogens v placebo for premenstrual symptoms*

Outcomes Treatment Route of administration Standardised mean difference (95% CI)
SymptomReduction Progesterone All -0.03 (-0.04 to -0.02)
Suppositories -0.04 (0.03 to 0.05)
Oral -0.15 (-0.17 to -0.12)
Progestogens All -0.04 (-0.06 to -0.01)
Odds ratio (CI)
*Negative standardised mean differences indicate a benefit for treatment.
†Difference favours placebo group and is not statistically significant.
Withdrawals resulting from side effects Progesterone All 1.7 (0.4 to 6.8)†
Progestogens All 1.7 (0.9 to 3.2)†

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