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Evid Based Mental Health 4:117 doi:10.1136/ebmh.4.4.117
  • Therapeutics

Nortriptyline plus lithium increased time to relapse in unipolar depressed patients who responded to electroconvulsive therapy

Relapse rates for nortriptyline plus lithium v nortriptyline alone v placebo for depressed patients who responded to electroconvulsive therapy‡

Comparisons at 24 weeks Event rates RRR (95% CI) NNT (CI)
‡Abbreviations defined in glossary; RRR, NNT, and CI calculated from data in article.
Nortriptyline v placebo 60% v 84% 29% (−1 to 53) Not significant
Nortriptyline + lithium v placebo 39% v 84% 53% (25 to 74) 3 (2 to 6)
Nortriptyline + lithium v nortriptyline alone 39% v 60% 35% (−16 to 65) Not significant

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