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Evid Based Mental Health 3:58 doi:10.1136/ebmh.3.2.58
  • Aetiology

Review: most antipsychotic drugs are associated with weight gain

Estimated weight change in patients taking study drugs

Drug Estimated mean weight change (kg) at 10 weeks (95% CI)*
*Mean weight change for one drug is statistically different from another when CIs do not overlap.
Placebo −0.7 (−1.6 to 0.1)
Molindone −0.4 (−2.4 to 1.7)
Ziprasidone 0.04 (−0.5 to 0.6)
Fluphenazine 0.4 (−0.7 to 1.5)
Haloperidol 1.1 (0.4 to 1.8)
Nonpharmacologic control 1.3 (0.8 to 1.8)
Polypharmacy 1.8 (0.8 to 2.8)
Risperidone 2.1 (1.7 to 2.5)
Chlorpromazine 2.6 (0.9 to 4.3)
Sertindole 2.9 (1.8 to 4.1)
Thioridazine/mesordazine 3.2 (1.4 to 5.0)
Olanzapine 4.2 (3.8 to 4.5)
Clozapine 4.5 (3.0 to 5.9)

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