Article Text

PDF
A negative randomised sham-controlled trial of ventral capsule/ventral striatum stimulation in treatment-resistant depression: an unsuccessful trial or treatment?
  1. Rajamannar Ramasubbu
  1. Department of Psychiatry/Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; rramasub@ucalgary.ca

Statistics from Altmetric.com

ABSTRACT FROM: Dougherty DD, Rezai AR, Carpenter LL, et al. A randomized sham-controlled trial of deep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression. Biol Psychiatry 2014. Published Online First.

What is already known on this topic

The evidence from multiple open-label trials documents the efficacy and safety of Deep brain stimulation (DBS) in the treatment of refractory depression (TRD).1 Nonetheless, randomised sham-control trials are required to determine whether the effect is directly related to active electrical stimulation or to the non-stimulation effects.

Methods of the study

This was a multicentre randomised sham-controlled trial of DBS at the ventral capsule/ventral striatum (VC/VS). Thirty patients with chronic, non-psychotic, unipolar TRD were recruited from five centres that used comparable surgical targeting, in the USA. Patients received active or sham stimulation (1:1) in a double-blinded fashion for 16 weeks, followed by a 24-month open-label phase of active stimulation. During the blinded phase, high-frequency bilateral stimulation with two different fixed pulse …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.