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Causes and risk factors
More evidence of an association between antipsychotic drugs and the risk of diabetes in children and adolescents: a population-based study
  1. William V Bobo
  1. Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN 55905, USA; bobo.william@mayo.edu

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ABSTRACT FROM: Nielsen RE, Laursen MF, Vernal DL, et al. Risk of diabetes in children and adolescents exposed to antipsychotics: a nationwide 12-year case-control study. J Am Acad Child Adolesc Psychiatry 2014;53:971–9.e6.

What is already known on this topic

Second generation antipsychotics have been linked with heightened risk of clinically significant weight gain and adverse metabolic effects in adults, including new-onset type 2 diabetes.1 The use of these drugs has increased among children and adolescents in recent years, raising similar concerns about the risk of new-onset type 2 diabetes in that age group. Two previous large-scale epidemiological studies have reported an increase in such risk.2 ,3

Methods of the study

This was a retrospective, case–control study of 48 299 paediatric patients living in Denmark during the study period 1 January 1999 through 30 June 2010. Cohort members, exposures, outcomes and covariates for analysis were identified (or ascertained) using linked electronic medical care and prescription registers maintained by the Danish healthcare …

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