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Family-focused treatment improves attenuated psychotic symptoms, but does not differ from brief treatment in negative symptoms and social functioning in ultra high risk patients aged 12–35 years
  1. Mark van der Gaag
  1. Department of Clinical Psychology, VU University, Amsterdam, The Netherlands; m.vander.gaag{at}vu.nl

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ABSTRACT FROM: Miklowitz DJ, O'Brien MP, Schlosser DA, et al. Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial. J Am Acad Child Adolesc Psychiatry 2014;53:848–58.

What is already known on this topic?

Transition to psychotic episode can be reduced to about 50% by psychosocial interventions such as cognitive behavioural therapy (CBT), but there are no improvements in negative symptoms and social functioning.1 ,2 Antipsychotic medications are not usually indicated unless the person meets criteria for a DSM-IV/ICD-10 psychotic disorder.3

Methods of the study

The sample consisted of young ultra high risk (UHR) patients aged from 12 to 35 years as assessed with the Structured Interview for Prodromal Symptoms (SIPS) and the Scale of Prodromal Symptoms (SOPS). One hundred and twenty-nine participants were recruited at eight sites of the North American Prodrome Longitudinal Study and 102 were followed up at 6 months. The patients were randomised to 18 …

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