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Reduced cortical folding is a heritable feature of non-affective psychosis
  1. Lena Palaniyappan1,
  2. C Christoph Schultz2
  1. 1Division of Psychiatry & Applied Psychology, Translational Neuroimaging for Mental Health, University of Nottingham, C09, Institute of Mental Health, Triumph Road, Nottingham NG7 2TU, UK;
  2. 2Department of Psychiatry, Jena University Hospital, Jena, Germany
  1. Correspondence to Dr Lena Palaniyappan; Lena.Palaniyappan@nottingham.ac.uk

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ABSTRACT FROM: Nanda P, Tandon N, Mathew IT, et al. Local gyrification index in probands with psychotic disorders and their first-degree relatives. Biol Psychiatry 2014;76:447–55.

What is already known on this topic

In the last decade, the idea of defining state independent and heritable neurobiological variables (‘endophenotypes’) to characterise psychiatric illnesses has emerged in order to improve diagnosis, treatment and prognosis.1 Cortical folding, a characteristic feature of primate brain structure that shows a high degree of stability over the lifespan, has been considered a promising endophenotypic candidate in this regard.2 Recent studies have highlighted the diagnostic and prognostic relevance of cortical folding patterns in psychotic disorders,3 though findings have been inconsistent overall and the heritability of cortical folding changes seen in schizophrenia has been unclear.4

Methods of study

As a part of the Bipolar-Schizophrenia Network on Intermediate Phenotypes study (http://www.b-snip.org/website/index.htm), high-resolution anatomical scans were obtained from patients with schizophrenia (n=157), schizoaffective disorder (n=90), psychotic bipolar disorder (n=141), first-degree …

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