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Common childhood neurodevelopmental disorders are associated with increased risk of psychotic experiences in early adolescence
  1. Haseena Hussain1,
  2. Graham K Murray2
  1. 1Cambridgeshire and Peterborough NHS Foundation Trust, Brookside Child and Family Consultation Clinic, Cambridge, UK;
  2. 2Department of Psychiatry, University of Cambridge, Box 189, Addenbrooke's Hospital Cambridge, CB2 0QQ, UK
  1. Correspondence to Dr Graham K Murray; gm285{at}cam.ac.uk

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ABSTRACT FROM: Khandaker G, Stochl J, Zammit S, et al. A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. Psychol Med 2014;44:3229–38.

What is already known on this topic

The disturbance of normal brain development, dating from the prenatal or perinatal period, is a key tenet of the neurodevelopmental hypothesis of schizophrenia.1 Similarities exist between schizophrenia and certain neurodevelopmental disorders (NDDs) of childhood, such as autism and intellectual disability, which both increase the risk of psychotic outcomes.2–4 However, it is unknown whether there is any relationship between schizophrenia and many other NDDs, such as dyslexia, dyspraxia and dyscalculia, leaving it unclear as to whether the putative neurodevelopmental deficit in schizophrenia is general or very specific.

Methods of the study

The population of the study are from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. This consists of all pregnant women who were expecting births between April 1991 and December 1992 in the county of Avon, southwest England. …

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