Article Text

PDF
Twelve weeks' sertraline and CBT in young people with anxiety disorders increases likelihood of no longer having the diagnosis compared with placebo or monotherapy, but residual symptoms remain

Statistics from Altmetric.com

Question

Question: Is sertraline (SRT), cognitive behavioural therapy (CBT) or a combination of the two, effective at inducing remission among children and adolescents with anxiety disorders compared with placebo?

Patients: 488 children and adolescents aged between 7 and 17 years who met DSM-IV criteria for generalised anxiety disorder, social phobia and/or separation anxiety disorder.

Setting: Six sites, USA; from 2003 to 2008.

Intervention: SRT only, CBT only, SRT and CBT (COMB) or placebo pill treatment for 12 weeks.

Outcomes: Remission, defined in three different ways: (A) loss of all targeted anxiety disorders, assessed using the Anxiety Disorders Interview Schedule; (B) Clinical Global Impression Severity Scale (CGI-S) score of 1 (no symptoms) or 2 (minimal symptoms); (C) Clinical Global Impression Improvement Scale (CGI-I) score of 1 (very much improved).

Patient follow-up: 90% completed the study; 100% included in the analysis.

Methods

Design: Randomised controlled trial (the Child/Adolescent Anxiety Multimodal Study, CAMS).

Allocation: Unclear.

Blinding: The SRT and PBO arms were double blinded while the CBT and COMB arms were single blinded (assessors only).

Follow-up period: 12 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.