Atypical antipsychotics are associated with incident diabetes in older adults without schizophrenia or bipolar disorder

Question

Question: Is atypical antipsychotic use associated with incident diabetes or hyperlipidaemia in older people without schizophrenia or bipolar disorder?

People: Medicare advantage or commercial managed healthcare plan enrolees aged 65 and above with no history of schizophrenia, bipolar disorder, diabetes (for the hyperlipidaemia study) or hyperlipidaemia (for the diabetes study) in the previous year. In the diabetes study, cases were 13 075 people who initiated diabetes treatment between 2004 and 2008 (identification period), and controls were 65 375 people who had not received diabetes treatment during this time. In the hyperlipidaemia study, cases were 63 829 people newly started on hyperlipidaemia medication, and controls were 63 829 people who had not received hyperlipidaemia medication. Controls were matched to cases based on age, sex, health plan type and index date. The index date for cases was the date of first diabetes or hyperlipidaemia medication prescription fill. For controls, the index date was a randomly selected date in the identification period.

Setting: USA; from 2003 to 2008.

Risk factors: Atypical antipsychotic exposure in the year prior to diabetes or hyperlipidaemia treatment initiation (preindex …