Statistics from Altmetric.com
Question: Is schizophrenia associated with an increased risk of mortality, and do different classes of antipsychotics or other medications contribute to mortality risk?
People: 105 141 individuals were selected from the Agis Health Insurance Company database; 7415 patients with schizophrenia and 97 726 randomly selected controls. The schizophrenia case definition included a diagnosis-related group coding for schizophrenia in 2008 and at least one filled prescription for antipsychotic medication between 2006 and 2008. The schizophrenia group had a mean age of 45.5 years and the control group had a mean age of 39.9 years.
Setting: The urbanised population, central The Netherlands; from 2006 to 2008.
Risk factors: Having schizophrenia treated with an antipsychotic medication; taking different classes of antipsychotic medication (first generation, second generation or combination of the two); use of concomitant medications (anticholinergics, antidepressants, anxiolytics/hypnotics and/or mood stabilisers). All analyses were adjusted for age and sex.
Outcomes: All-cause mortality (in 2008 only).
Design: Retrospective cohort study.
Follow-up period: Mortality assessed over 1 year (assessed retrospectively).
There was a significantly higher death rate among people with schizophrenia who were taking antipsychotic …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.