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Depression 3 and 9 months after discharge is less common in cardiac patients who are receiving statins at discharge

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Question

Question

Is statin use associated with a reduced risk of developing depression after hospital discharge in individuals who have experienced a cardiac event or intervention?

Population

193 adults (mean age 64.14 years; 80.8% male; 34.7% with a history of depression), admitted to hospital for angioplasty, myocardial infarction or coronary artery bypass surgery.

Setting

A regional tertiary hospital in Geelong, Australia; recruitment from 2005 to 2006.

Prognostic factors

Statin prescription at discharge, as recorded in medical records. Analyses were adjusted for age, sex, functional status (assessed as effort tolerance measured with the physical functioning items in the Short Form-36), neuroticism (assessed using the International Personality Item Pool Representation of the Revised NEO Personality Inventory), history of depression, smoking, diabetes, body mass index, disease severity (defined using left ventricular ejection fraction) and aspirin therapy.

Outcomes

Major depressive disorder (MDD), or any depressive disorder (MDD, minor depression or dysthymia) at 3 months after discharge and depression at 9 months after discharge. ‘Baseline’ depression was assessed at 3 months postdischarge, to avoid potential confounder factors associated with acute illness and hospitalisation. …

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