Article Text

PDF
Sertraline and mirtazapine do not reduce severity of depression in people with dementia

Statistics from Altmetric.com

Question

Question

Are the two most commonly prescribed drugs for depression in dementia (sertraline and mirtazapine) efficacious and safe compared with placebo?

Patients

326 adults with probable or possible Alzheimer's disease (National Institute of Neurological and Communicative Diseases and Stroke – Alzheimer's Disease and Related Disorders Association criteria) and depression which lasted for ≥4 weeks and was assessed as potentially needing antidepressants by the referring psychiatrist. Participants also had to score ≥8 on the Cornell scale for depression in dementia (CSDD). The inclusion criteria were selected to reflect clinical practice. Individuals were excluded if they were clinically critical (eg, suicide risk), had contraindications to study drugs, were already on antidepressants or were without a carer.

Setting

Old-age psychiatry services in nine UK National Health Service (NHS) clinical centres in England; from January 2007 to October 2010.

Intervention

Sertraline (target dose 150 mg per day), mirtazapine (target dose 45 mg per day) or placebo (control). Participants began with one tablet (sertraline 50 mg, mirtazapine 15 mg or placebo), and the dose was increased to two tablets at week 2. At week 4, each participant undertook CSDD assessment and if their score was ≥4 the dose was increased to three tablets; and …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.