Statistics from Altmetric.com
In adolescents who are resistant to selective serotonin reuptake inhibitor (SSRI) treatment for major depressive disorder (MDD) what are the long-term outcomes for second step treatment options?
This was a naturalistic follow-up of participants in the Treatment of SSRI-Resistant Depression in Adolescents study, which recruited 334 adolescents between the ages of 12–18 years who had been diagnosed with DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) MDD that had not responded to treatment with an SSRI for 8 weeks.
Six clinical sites in the USA; 2001–2007.
Alternative SSRI or venlafaxine or alternative SSRI plus cognitive–behavioural therapy (CBT) or venlafaxine plus CBT for 12 weeks. Responders continued on their assigned treatment for an additional 12 weeks; non-responders were given open treatment. After 24 weeks, naturalistic treatment was given in the community.
Remission (≥3 consecutive weeks with ≤1 clinically significant symptom and no associated functional impairment on the Adolescent Longitudinal Interval Follow-up Evaluation (A-LIFE)); relapse (≥2 weeks with probable or possible depressive disorder on the A-LIFE (score of 3 or 4) after remission).
35% at 48 weeks and 39% at 72 weeks. Analyses used the last observation carried forward (LOCF) approach.
Naturalistic follow-up of a randomised controlled trial.
Medication was …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.