Article Text

PDF
Use of antidepressants for 12 weeks or longer is associated with a reduced incidence of heart attack in depressed adults

Statistics from Altmetric.com

Question

Question

Are antidepressants associated with an increased or decreased risk of incident myocardial infarction (MI) and all-cause mortality?

People

93 653 patients aged 25–80 years (average age 51.5 years, 14.1% female, 77.8% White, 57.1% not married) identified using the US Department of Veterans Affairs database, who had either one inpatient or at least two outpatient codes for depression in their records between 1 October 1999 and 30 September 2000. Patients with at least one primary or secondary diagnosis of heart or cardiovascular disease, or with psychotic or bipolar disorders, were excluded. Patients were excluded from the analyses if a MI occurred within 1 month of follow-up; they did not receive a 12-week follow-up from baseline if they only had a diagnosis of dysthymia or psychotic disorders of bipolar disorder.

Setting

Veterans Health Administration, USA; 1999–2007.

Risk factors

12 weeks or longer of continuous antidepressant treatment with the same drug compared with 0–11 weeks of continuous antidepressant treatment. Antidepressant use was assessed using Pharmacy Benefits Management records, and the drug classified as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.