Article Text

PDF
Adding a psychosocial intervention to antipsychotic medication reduces treatment discontinuation and relapse

Statistics from Altmetric.com

Question

Question

Is it more effective to treat early stage schizophrenia with a combination of antipsychotic medication and psychosocial invention, compared with medication alone?

Patients

1268 people (16–50 years old) with early stage DSM-IV schizophrenia or schizophreniform disorder diagnosed in the past 5 years. Participants were receiving treatment with one of seven specified antipsychotics and living with family members who could be involved in their care.

Setting

10 outpatient clinics in China; January 2005 to October 2007.

Intervention

Antipsychotic medication alone compared with antipsychotic medication plus psychosocial intervention for 12 months. The intervention comprised psychoeducation, family intervention, skills training and CBT, each delivered as a 1 h session every month.

Outcomes

Primary outcomes: Treatment discontinuation or change, and time to treatment discontinuation. Secondary outcomes: Adherence (defined as taking ≥70% of medications), relapse (defined as any one of psychiatric hospitalisation, increase in level of care needed plus ≥25% increase in Positive and Negative Syndrome Scale (PANSS) total score, Clinical Global Impressions Scale score of much or very much worse, deliberate self injury, clinically significant suicidal …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.