Article Text

PDF
Quetiapine is effective in the treatment of adults in the acute phase of bipolar depression

Statistics from Altmetric.com

Question

Question

Are quetiapine and lithium monotherapy effective and well-tolerated treatments for a major depressive episode in bipolar disorder?

Patients

802 adult (aged 18–65 years) outpatients with DSM-IV-defined bipolar disorder I or II (with or without rapid cycling; ≥4 episodes/year to ≤8 per year) who were experiencing an episode of depression (onset ≥4 weeks; duration ≤1 year), Hamilton Depression Rating Scale (HDRS) score ≥20 and an HDRS item 1 (depressed mood) score ≥2. See online notes for exclusion criteria.

Setting

Multicentre throughout Europe, Canada and Asia; August 2005 to May 2007.

Intervention

300 mg/day of quetiapine, 600 mg/day of quetiapine, 600–1800 mg/day of lithium or placebo. Treatment randomisation was stratified by bipolar diagnosis (I or II) and within strata in a 2:2:1:1 ratio to quetiapine 300 mg/day, quetiapine 600 mg/day, lithium 600–1800 mg/day or placebo.

Outcomes

Primary outcome was improvement in depression measured as a change in the total score on the Montgomery-Asberg Depression Rating Scale (MADRS) from baseline to week 8. Analysis of covariance was used with baseline MADRS total score as covariate, country as random effect and treatment and diagnosis strata as …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles