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Review: Is aripiprazole as effective as risperidone in people with schizophrenia?

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Question

Question:

What are the effects of aripiprazole compared with other atypical antipsychotics in people with schizophrenia and schizophrenia-like psychoses?

Outcomes:

Efficacy (as defined by each study), adverse effects.

Methods

Design:

Systematic review with meta-analysis.

Data sources:

Cochrane Schizophrenia Group's Specialised Register was searched from inception to March 2007 for randomised controlled trials (RCTs). Reference lists of identified studies were hand searched. First authors of included studies were contacted for missing information, and drug companies were contacted for additional data.

Study selection and analysis:

Reviewers appraised studies and selected RCTs comparing oral aripiprazole with oral forms of risperidone, quetiapine, olanzapine, amisulpride, aripiprazole, clozapine, sertindole, ziprasidone or zotepine in people with schizophrenia and schizophrenia-like psychoses. Data were extracted independently. Weighted mean differences (MD) were calculated for continuous data. Dichotomous data were used to calculate RR using a random-effects model. Heterogeneity was investigated using the I2 statistic.

Main results

Four RCTs met inclusion criteria (n = 1,404). Data were available that compared aripiprazole with olanzapine and risperidone. Overall, 38.5% of participants left the included studies prematurely, but there were no significant differences between groups. Aripiprazole was less effective than olanzapine in terms of positive and negative symptoms of Schizophrenia total …

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