Article Text

PDF
Subcutaneous naltrexone implants reduce opioid use in opiate dependent patients

Statistics from Altmetric.com

Question

Question:

Does a 6 month naltrexone implant reduce opioid use after inpatient treatment compared with usual care?

Patients:

56 opiate dependent patients (>18 years) who completed an inpatient treatment programme based on drug abstinence. Exclusion criteria: pregnant, psychotic or serious liver disease (except latent hepatitis C).

Setting:

Two addiction treatment centres, Norway; 1 January 2006-1 July 2007.

Intervention:

Subcutaneous naltrexone implant (2.2g naltrexone) versus usual care (counselling, access to maintenance programmes, hospital and community services, as needed).

Outcomes:

Primary outcomes: self-reported opioid use (heroin, morphine, codeine, methadone, or buprenorphine; number of days of opioid use in previous 30 days; frequency of use within the 6 month trial period); number of overdoses. Primary outcomes were derived from the Addiction Severity Index and the timeline follow-back interview technique. Secondary outcomes included: number of participants meeting DSM-IV opioid dependence and abuse (Mini International Neuropsychiatric Interview); other drug use; depression (Beck Depression Inventory and Hopkins Symptom Checklist-depression sub-scale); and life satisfaction (Temporal Satisfaction with Life Scale ‘present'). Satisfaction with treatment over the study period and craving were assessed using visual analogue scales.

Patient follow-up

52 (93%) …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles