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Review: statins do not protect against development of dementia

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Question

Question:

Are statins effective for prevention of dementia?

Outcomes:

Objective diagnosis of dementia, Alzheimer’s disease or vascular dementia using standardised criteria; or change in Mini-Mental State Examination (MMSE), Alzheimer’s Disease Assessment Scale-Cognitive or other standardised tests of cognitive performance in patients at risk of Alzheimer’s disease/vascular dementia.

Methods

Design:

Systematic review.

Data sources:

MEDLINE, EMBASE, The Specialised Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, PsycINFO, CINAHL and LILACS (searched from inception to October 2007), in addition to conference proceedings, theses and ongoing trials.

Study selection and analysis:

Two reviewers independently selected and appraised double blind, randomised, placebo controlled trials comparing any statin with placebo (administered for a minimum of 12 months) in people with normal cognitive function but of sufficient age to be at risk of Alzheimer’s disease (including those at risk of cerebrovascular disease). Exclusions: direct comparison trials or those without a control group.

Main results

Two randomised placebo controlled trials were eligible for inclusion: The Medical Research Council/British Heart Foundation funded Heart Protection Study …

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