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Cognitive decline fastest in people with Alzheimer’s disease compared with other dementias

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Question

Question:

Are there differences in demographic features, cognitive decline and survival among people with vascular dementia, Alzheimer’s disease or Alzheimer’s disease with cerebrovascular disease?

Population:

970 of 3545 consecutive patients who were: diagnosed with “probable” vascular dementia (VaD; neuroepidemiology branch of the US National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l’Enseignement en Neurosciences criteria); “probable” or “definite” Alzheimer’s disease (AD; National Institute of Neurologic and Communicative Disorders and Stroke and the AD and Related Disorders Association criteria); or Alzheimer’s disease with cerebrovascular disease (AD+CVD; clinical criteria for possible AD as for AD alone, plus clinical or brain imaging evidence of CVD). In addition, participants had to be examined at least twice for a minimum of 1 year, and have had a Dementia Rating Scale (DRS) measurement during the year of the first visit. The 2575 excluded patients did not meet the above inclusion criteria.

Setting:

Lille-Bailleur memory clinic, France; recruitment 1995–2001.

Prognostic factors:

Standardised examinations comprising neurological, behavioural, neuropsychological, imaging and laboratory assessments were performed on …

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