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Schizophrenia in either parent increases risk of infant mortality

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QUESTION

Question:

Is schizophrenia in either parent associated with adverse pregnancy outcomes?

People:

1 890 550 women delivering singleton births from 1983 to 2002, their children and the biological fathers of those children. Information on births was obtained from the Medical Birth Register, and linked with the Hospital Discharge Register, the Multi-Generation Register (information on children and their parents), the Cause of Death Register and the Education Register.

Setting:

Sweden; 1977–2002.

Risk factors:

Maternal or paternal schizophrenia. The definition of schizophrenia was at least one hospital admission (ICD-8, ICD-9 or ICD-10 codes) during 1977–2002, and was recorded for mothers, fathers and the parents’ full and half siblings. Logistic regression analysis was used to estimate risk for adverse pregnancy outcomes controlling for possible confounding factors of schizophrenia in the spouse, maternal age, parity, maternal and paternal education, maternal smoking and cohabitation status.

Outcomes:

Adverse pregnancy outcomes: infant death (defined as death within the first year of life), low birth weight (<2500 g), preterm delivery (⩽36 weeks) and …

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