Article Text

PDF
Escitalopram modestly improves generalised anxiety disorder in older adults in treatment completers

Statistics from Altmetric.com

QUESTION

Question:

Is escitalopram an effective, tolerable and safe treatment for generalised anxiety disorder in older adults?

Patients:

179 older adults (⩾60 years old) with a primary diagnosis of generalised anxiety disorder (GAD; DSM-IV criteria) and a Hamilton Anxiety Rating Scale (HAM-A) score ⩾17. Main exclusions: current antidepressant or anxiolytic use (up to 2 mg/day lorazepam equivalent was allowed); psychotic or bipolar disorder; current suicidal ideation; unstable medical condition; and current psychotherapy.

Setting:

Primary care and other outpatient clinics, Pittsburgh, Pennsylvania, USA; January 2005 to January 2008.

Intervention:

Escitalopram (10 mg/day with an increase to 20 mg/day allowed after 4 weeks depending on clinical response) or placebo for 12 weeks.

Outcomes:

Primary efficacy measure: response (Clinical Global Impressions Scale-Improvement (CGI-I) score of very much or much improved based on the assessor’s perception of improvement, anxiety scale scores and patient self-report). Secondary outcomes: HAM-A scale score, Penn State Worry Questionnaire, Late Life Function and Disability Instrument score, Medical Outcome Survey 36-item short form score (SF-36), patient reported adverse effects (open question).

Patient follow-up:

80.4% completed treatment, 98.9% included in analyses.

METHODS

Design:

Randomised controlled trial.

Allocation:

Concealed.

Blinding:

Double blind.

Follow-up period:

12 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.